Version 5.4
Mus musculus Gene: Xrcc1
Summary
InnateDB Gene IDBG-155000.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Xrcc1
Gene Name X-ray repair complementing defective repair in Chinese hamster cells 1
Synonyms Xrcc-1
Species Mus musculus
Ensembl Gene ENSMUSG00000051768
Encoded Proteins
IDBP-155002
X-ray repair complementing defective repair in Chinese hamster cells 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073050:
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:24547150-24573438
Strand Forward strand
Band A3
Transcripts
ENSMUST00000063249 ENSMUSP00000070995
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003684 damaged DNA binding
GO:0005515 protein binding
Biological Process
GO:0000012 single strand break repair
GO:0001666 response to hypoxia
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006974 cellular response to DNA damage stimulus
GO:0010033 response to organic substance
GO:0021766 hippocampus development
GO:0042493 response to drug
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000073050
View Gene Order
ENSBTAG00000016268
Not yet available
Pathways
NETPATH
REACTOME
REACT_231541
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_245705
Base Excision Repair pathway
REACT_233397
DNA Repair pathway
REACT_250836
Resolution of Abasic Sites (AP sites) pathway
KEGG
mmu03410
Base excision repair pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_933
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_1893
Resolution of Abasic Sites (AP sites) pathway
REACT_1104
Base Excision Repair pathway
REACT_216
DNA Repair pathway
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
e2f_pathway
E2F transcription factor network
foxm1pathway
FOXM1 transcription factor network
Cross-References
SwissProt Q60596
TrEMBL
UniProt Splice Variant
Entrez Gene 22594
UniGene Mm.404773 Mm.4347
RefSeq NM_009532 XM_006539737 XM_006539738
OMIM
CCDS CCDS20955
HPRD
IMGT
MGI ID MGI:99137
MGI Symbol Xrcc1
EMBL AK168334 BC055900 BC085281 U02887
GenPept AAA93115 AAH55900 AAH85281 BAE40272
RNA Seq Atlas 22594

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca