InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pvrl1

Summary

InnateDB Gene

IDBG-155297.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pvrl1

Gene Name

poliovirus receptor-related 1

Synonyms

AI835281; AW549174; Cd111; HIgR; HveC; nectin-1; PRR; PRR1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032012

Encoded Proteins

IDBP-155299

poliovirus receptor-related 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110400:
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:43744576-43807454

Strand

Forward strand

Band

A5.1

Transcripts

ENSMUST00000034510

ENSMUSP00000034510

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0046790	virion binding
GO:0046982	protein heterodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002089	lens morphogenesis in camera-type eye
GO:0002934	desmosome organization
GO:0006826	iron ion transport
GO:0007156	homophilic cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007411	axon guidance
GO:0016337	single organismal cell-cell adhesion
GO:0046718	viral entry into host cell
GO:0048593	camera-type eye morphogenesis
GO:0051963	regulation of synapse assembly
GO:0060041	retina development in camera-type eye
GO:0070166	enamel mineralization

Cellular Component

GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0016021	integral component of membrane
GO:0016342	catenin complex
GO:0030424	axon
GO:0032584	growth cone membrane
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043231	intracellular membrane-bounded organelle
GO:0045202	synapse