InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pvrl1

Summary

InnateDB Protein

IDBP-155299.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pvrl1

Protein Name

poliovirus receptor-related 1

Synonyms

AI835281; AW549174; Cd111; HIgR; HveC; nectin-1; PRR; PRR1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034510

InnateDB Gene

IDBG-155297 (Pvrl1)

Protein Structure

UniProt Annotation

Function

Involved in cell adhesion and synaptogegesis. Has some neurite outgrowth-promoting activity. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells. {ECO:0000269PubMed:11827984, ECO:0000269PubMed:22955284}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11827984}; Single-pass type I membrane protein {ECO:0000269PubMed:11827984}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269PubMed:11827984}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0046790	virion binding
GO:0046982	protein heterodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002089	lens morphogenesis in camera-type eye
GO:0002934	desmosome organization
GO:0006826	iron ion transport
GO:0007156	homophilic cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007411	axon guidance
GO:0016337	single organismal cell-cell adhesion
GO:0046718	viral entry into host cell
GO:0048593	camera-type eye morphogenesis
GO:0051963	regulation of synapse assembly
GO:0060041	retina development in camera-type eye
GO:0070166	enamel mineralization

Cellular Component

GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0016021	integral component of membrane
GO:0016342	catenin complex
GO:0030424	axon
GO:0032584	growth cone membrane
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043231	intracellular membrane-bounded organelle
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:1926483

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00406
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JKF6