Version 5.4
Mus musculus Gene: Otx2
Summary
InnateDB Gene IDBG-155303.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Otx2
Gene Name orthodenticle homolog 2 (Drosophila)
Synonyms E130306E05Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000021848
Encoded Proteins
IDBP-401364
orthodenticle homolog 2 (Drosophila)
IDBP-401360
orthodenticle homolog 2 (Drosophila)
IDBP-401359
orthodenticle homolog 2 (Drosophila)
IDBP-401358
orthodenticle homolog 2 (Drosophila)
IDBP-535763
orthodenticle homolog 2 (Drosophila)
IDBP-539460
orthodenticle homolog 2 (Drosophila)
IDBP-539091
orthodenticle homolog 2 (Drosophila)
IDBP-535042
orthodenticle homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that belongs to the homeobox family of transcription factors. The encoded protein plays a role in the development and patterning of the head. This protein regulates development of the choroid plexuses in the brain affecting composition of cerebrospinal fluid in the developing brain and is thought to function in the development of sense organs in the embryo. In humans, mutations in this gene are associated with pituitary hormone deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:48657679-48667644
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000118578 ENSMUSP00000113690
ENSMUST00000119070 ENSMUSP00000112532
ENSMUST00000122009 ENSMUSP00000113930
ENSMUST00000119739 ENSMUSP00000113586
ENSMUST00000135279 ENSMUSP00000123046
ENSMUST00000152018 ENSMUSP00000123454
ENSMUST00000144465 ENSMUSP00000116630
ENSMUST00000133479 ENSMUSP00000122200
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001708 cell fate specification
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006461 protein complex assembly
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0007492 endoderm development
GO:0009887 organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0022037 metencephalon development
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0032525 somite rostral/caudal axis specification
GO:0042472 inner ear morphogenesis
GO:0042706 eye photoreceptor cell fate commitment
GO:0045165 cell fate commitment
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048663 neuron fate commitment
GO:0048664 neuron fate determination
GO:0048852 diencephalon morphogenesis
GO:0048856 anatomical structure development
GO:0090009 primitive streak formation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030426 growth cone
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165588
View Gene Order
ENSBTAG00000014741
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.134516 Mm.405632 Mm.487292
RefSeq NM_001286481 NM_001286483 NM_144841 XM_006518689 XM_006518690 XM_006518691 XM_006518692 XM_006518694
OMIM
CCDS CCDS49473 CCDS70575
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca