Version 5.4
Mus musculus Protein: Otx2
Summary
InnateDB Protein IDBP-539091.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Otx2
Protein Name orthodenticle homolog 2 (Drosophila)
Synonyms E130306E05Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000116630
InnateDB Gene IDBG-155303 (Otx2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001708 cell fate specification
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007417 central nervous system development
GO:0007492 endoderm development
GO:0009887 organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0022037 metencephalon development
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0032525 somite rostral/caudal axis specification
GO:0042472 inner ear morphogenesis
GO:0042706 eye photoreceptor cell fate commitment
GO:0045165 cell fate commitment
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048663 neuron fate commitment
GO:0048664 neuron fate determination
GO:0048852 diencephalon morphogenesis
GO:0048856 anatomical structure development
GO:0090009 primitive streak formation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:97451
InterPro IPR001356 Homeobox domain
IPR009057 Homeodomain-like
PFAM PF00046
PRINTS
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3Z4G2
UniProt Splice Variant
Entrez Gene 18424
UniGene Mm.487292
RefSeq
MGI ID
MGI Symbol Otx2
OMIM
CCDS
HPRD
IMGT
EMBL AC166574
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca