Version 5.4
Mus musculus Gene: Cidea
Summary
InnateDB Gene IDBG-155334.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cidea
Gene Name cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
Synonyms AW212747
Species Mus musculus
Ensembl Gene ENSMUSG00000024526
Encoded Proteins
IDBP-155336
cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176194:
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:67343564-67367794
Strand Forward strand
Band E1
Transcripts
ENSMUST00000025404 ENSMUSP00000025404
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001659 temperature homeostasis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006629 lipid metabolic process
GO:0006915 apoptotic process
GO:0008219 cell death
GO:0010890 positive regulation of sequestering of triglyceride
GO:0019915 lipid storage
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032720 negative regulation of tumor necrosis factor production
GO:0035634 response to stilbenoid
GO:0050710 negative regulation of cytokine secretion
GO:0050995 negative regulation of lipid catabolic process
GO:1900118 negative regulation of execution phase of apoptosis
GO:1902510 regulation of apoptotic DNA fragmentation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005811 lipid particle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000176194
View Gene Order
ENSBTAG00000046547
Not yet available
Cross-References
SwissProt O70302
TrEMBL
UniProt Splice Variant
Entrez Gene 12683
UniGene
RefSeq NM_007702
OMIM
CCDS CCDS37846
HPRD
IMGT
MGI ID MGI:1270845
MGI Symbol Cidea
EMBL AC154125 AF041376 BC096649 CH466528
GenPept AAC34985 AAH96649 EDL09649 EDL09650
RNA Seq Atlas 12683

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca