InnateDB Protein
|
IDBP-155336.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Cidea
|
Protein Name
|
cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
|
Synonyms
|
AW212747;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000025404
|
InnateDB Gene
|
IDBG-155334 (Cidea)
|
Protein Structure
|
|
Function |
Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear. {ECO:0000269PubMed:18509062, ECO:0000269PubMed:22144693, ECO:0000269PubMed:22245780, ECO:0000269PubMed:9564035}.
|
Subcellular Localization |
Lipid droplet. Nucleus. Note=Enriched at lipid droplet contact sites. Using a GFP-tagged construct, has been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (PubMed:12910269). These data could not be confirmed (PubMed:22245780, PubMed:18509062). {ECO:0000269PubMed:12910269, ECO:0000269PubMed:18509062, ECO:0000269PubMed:22245780}.
|
Disease Associations |
|
Tissue Specificity |
Highly expressed in brown adipose tissue and, at lower levels, in white adipose tissue (at protein level). Expressed in mammary gland during pregnancy and lactation, in epithelial cells, but not in the surrounding adipose tissue. Secreted into milk via milk fat globules. Undetectable in undifferentiated preadipocytes. {ECO:0000269PubMed:12910269, ECO:0000269PubMed:18509062, ECO:0000269PubMed:22245780}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
|
Protein-Protein |
11
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1270845
|
InterPro |
IPR003508
CIDE-N domain
|
PFAM |
PF02017
|
PRINTS |
|
PIRSF |
|
SMART |
SM00266
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O70302
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
12683
|
UniGene |
|
RefSeq |
NP_031728
|
MGI ID |
|
MGI Symbol |
Cidea
|
OMIM |
|
CCDS |
CCDS37846
|
HPRD |
|
IMGT |
|
EMBL |
AC154125
AF041376
BC096649
CH466528
|
GenPept |
AAC34985
AAH96649
EDL09649
EDL09650
|
|
|