InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dgat1

Summary

InnateDB Gene

IDBG-155428.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dgat1

Gene Name

diacylglycerol O-acyltransferase 1

Synonyms

ARAT; C75990; D15Ertd23e; Dgat

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022555

Encoded Proteins

IDBP-155430

diacylglycerol O-acyltransferase 1

IDBP-534096

diacylglycerol O-acyltransferase 1

IDBP-535139

diacylglycerol O-acyltransferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185000:
The enzyme encoded by this gene utilizes diacylglycerol and fatty acyl CoA as substrates in order to catalyze the final stage of triacylglycerol synthesis. It is also involved in cellular as well as physiological metabolic processes. [provided by RefSeq, Jul 2008]
This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:76502015-76511951

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023214	ENSMUSP00000023214
ENSMUST00000160294
ENSMUST00000159908
ENSMUST00000162354	ENSMUSP00000123802
ENSMUST00000160293	ENSMUSP00000123779
ENSMUST00000162813
ENSMUST00000161499
ENSMUST00000159776

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003846	2-acylglycerol O-acyltransferase activity
GO:0004144	diacylglycerol O-acyltransferase activity
GO:0005515	protein binding
GO:0050252	retinol O-fatty-acyltransferase activity

Biological Process

GO:0019432	triglyceride biosynthetic process
GO:0019915	lipid storage
GO:0034379	very-low-density lipoprotein particle assembly
GO:0035336	long-chain fatty-acyl-CoA metabolic process
GO:0042572	retinol metabolic process
GO:0046339	diacylglycerol metabolic process
GO:0055089	fatty acid homeostasis