InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dgat1

Summary

InnateDB Protein

IDBP-155430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dgat1

Protein Name

diacylglycerol O-acyltransferase 1

Synonyms

ARAT; C75990; D15Ertd23e; Dgat;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023214

InnateDB Gene

IDBG-155428 (Dgat1)

Protein Structure

UniProt Annotation

Function

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. {ECO:0000269PubMed:19028692, ECO:0000269PubMed:20876538, ECO:0000269PubMed:22493088}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:20876538}; Multi-pass membrane protein {ECO:0000269PubMed:20876538}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003846	2-acylglycerol O-acyltransferase activity
GO:0004144	diacylglycerol O-acyltransferase activity
GO:0005515	protein binding
GO:0050252	retinol O-fatty-acyltransferase activity

Biological Process

GO:0019432	triglyceride biosynthetic process
GO:0019915	lipid storage
GO:0034379	very-low-density lipoprotein particle assembly
GO:0035336	long-chain fatty-acyl-CoA metabolic process
GO:0042572	retinol metabolic process
GO:0046339	diacylglycerol metabolic process
GO:0055089	fatty acid homeostasis