InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Chmp3

Summary

InnateDB Gene

IDBG-155723.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chmp3

Gene Name

charged multivesicular body protein 3

Synonyms

25.1; 4921505F14Rik; 9130011K15Rik; CGI-49; D6Ertd286e; NEDF; Vps24

Species

Mus musculus

Ensembl Gene

ENSMUSG00000053119

Encoded Proteins

IDBP-155725

charged multivesicular body protein 3

IDBP-252329

charged multivesicular body protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115561:
This locus represents naturally occurring read-through transcription between the neighboring RNF103 (ring finger protein 103) and CHMP3 (charged multivesicular body protein 3) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Oct 2011] This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:71543797-71582609

Strand

Forward strand

Band

Transcripts

ENSMUST00000065364	ENSMUSP00000068410
ENSMUST00000059462	ENSMUSP00000109815
ENSMUST00000127774
ENSMUST00000132917
ENSMUST00000142169
ENSMUST00000128382

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding

Biological Process

GO:0007049	cell cycle
GO:0008333	endosome to lysosome transport
GO:0015031	protein transport
GO:0032467	positive regulation of cytokinesis
GO:0051036	regulation of endosome size
GO:0051301	cell division