InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHMP3

Summary

InnateDB Gene

IDBG-59881.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHMP3

Gene Name

charged multivesicular body protein 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000115561

Encoded Proteins

IDBP-59883

charged multivesicular body protein 3

IDBP-295337

charged multivesicular body protein 3

IDBP-295299

charged multivesicular body protein 3

IDBP-382090

charged multivesicular body protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This locus represents naturally occurring read-through transcription between the neighboring RNF103 (ring finger protein 103) and CHMP3 (charged multivesicular body protein 3) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Oct 2011] This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:86503430-86620493

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000263856	ENSP00000263856
ENST00000393773
ENST00000409727	ENSP00000387045
ENST00000409810
ENST00000409225	ENSP00000386590
ENST00000439940	ENSP00000405575
ENST00000494623
ENST00000486404
ENST00000466032
ENST00000485465

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007034	vacuolar transport
GO:0007049	cell cycle
GO:0015031	protein transport
GO:0016032	viral process
GO:0016197	endosomal transport
GO:0019058	viral life cycle
GO:0050792	regulation of viral process
GO:0051301	cell division
GO:0061024	membrane organization
GO:1902188	positive regulation of viral release from host cell

Cellular Component

GO:0005829	cytosol
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000053119

View Gene Order

ENSBTAG00000013589

Not yet available

Pathways

NETPATH

REACTOME

REACT_6361

Late Phase of HIV Life Cycle pathway

REACT_27258

Endosomal Sorting Complex Required For Transport (ESCRT) pathway

REACT_6256

HIV Life Cycle pathway

REACT_6185

HIV Infection pathway

REACT_6359

Budding and maturation of HIV virion pathway

REACT_116125

Disease pathway

REACT_11123

Membrane Trafficking pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

erbb1_internalization_pathway

Internalization of ErbB1

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.591582

RefSeq

NM_001005753 NM_001193517 NM_016079

HUGO

OMIM

CCDS

CCDS33236 CCDS42707 CCDS54375 CCDS56128

HPRD

15650

IMGT

EMBL

GenPept

RNA Seq Atlas