Version 5.4
| Mus musculus Gene: Tnfsf8 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-155788.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Tnfsf8 | ||||||||
| Gene Name | tumor necrosis factor (ligand) superfamily, member 8 | ||||||||
| Synonyms | CD153; Cd30l; CD30LG | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000028362 | ||||||||
| Encoded Proteins |
tumor necrosis factor (ligand) superfamily, member 8
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106952:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin\'s and some non-Hodgkin\'s lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 4:63831308-63861347 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | C1 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Cytokine-cytokine receptor interaction pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Cytokine-cytokine receptor interaction pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | P32972 | ||||||||
| TrEMBL | Q3U033 Q544U1 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 21949 | ||||||||
| UniGene | Mm.4664 | ||||||||
| RefSeq | NM_009403 XM_006537778 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS18264 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:88328 | ||||||||
| MGI Symbol | Tnfsf8 | ||||||||
| EMBL | AK030916 AK157270 BC117093 BC117097 CH466527 L09754 | ||||||||
| GenPept | AAA74595 AAI17094 AAI17098 BAC27182 BAE34022 EDL31091 | ||||||||
| RNA Seq Atlas | 21949 | ||||||||