InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gdi1

Summary

InnateDB Gene

IDBG-155873.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gdi1

Gene Name

guanosine diphosphate (GDP) dissociation inhibitor 1

Synonyms

GDIA; GDIalpha

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015291

Encoded Proteins

IDBP-155875

guanosine diphosphate (GDP) dissociation inhibitor 1

IDBP-539233

guanosine diphosphate (GDP) dissociation inhibitor 1

IDBP-537505

guanosine diphosphate (GDP) dissociation inhibitor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000203879:
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:74304998-74311862

Strand

Forward strand

Band

A7.3

Transcripts

ENSMUST00000015435	ENSMUSP00000015435
ENSMUST00000146013
ENSMUST00000145580
ENSMUST00000149391
ENSMUST00000153141	ENSMUSP00000119805
ENSMUST00000128915
ENSMUST00000144317
ENSMUST00000130581	ENSMUSP00000122146
ENSMUST00000137447
ENSMUST00000135041

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005093	Rab GDP-dissociation inhibitor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0017137	Rab GTPase binding

Biological Process

GO:0015031	protein transport
GO:0032482	Rab protein signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0050771	negative regulation of axonogenesis
GO:0050790	regulation of catalytic activity
GO:0051592	response to calcium ion
GO:0090315	negative regulation of protein targeting to membrane