InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gdi1

Summary

InnateDB Protein

IDBP-155875.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gdi1

Protein Name

guanosine diphosphate (GDP) dissociation inhibitor 1

Synonyms

GDIA; GDIalpha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015435

InnateDB Gene

IDBG-155873 (Gdi1)

Protein Structure

UniProt Annotation

Function

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.

Subcellular Localization

Cytoplasm {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}.

Disease Associations

Tissue Specificity

High expression in brain, lower in other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005093	Rab GDP-dissociation inhibitor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0017137	Rab GTPase binding

Biological Process

GO:0015031	protein transport
GO:0032482	Rab protein signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0050771	negative regulation of axonogenesis
GO:0050790	regulation of catalytic activity
GO:0051592	response to calcium ion
GO:0090315	negative regulation of protein targeting to membrane