InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dbn1

Summary

InnateDB Gene

IDBG-155945.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dbn1

Gene Name

drebrin 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034675

Encoded Proteins

IDBP-155947

drebrin 1

IDBP-261352

drebrin 1

IDBP-261354

drebrin 1

IDBP-532516

drebrin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113758:
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer\'s disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:55473429-55488111

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021950	ENSMUSP00000021950
ENSMUST00000109923	ENSMUSP00000105549
ENSMUST00000109921	ENSMUSP00000105547
ENSMUST00000135705
ENSMUST00000139516
ENSMUST00000139275	ENSMUSP00000122574
ENSMUST00000124480
ENSMUST00000127867
ENSMUST00000175813

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005522	profilin binding

Biological Process

GO:0007015	actin filament organization
GO:0007399	nervous system development
GO:0010643	cell communication by chemical coupling
GO:0010644	cell communication by electrical coupling
GO:0032507	maintenance of protein location in cell
GO:0048699	generation of neurons
GO:0061351	neural precursor cell proliferation

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005921	gap junction
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000113758

View Gene Order

ENSBTAG00000011400

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.19016

RefSeq

NM_001177371 NM_001177372 NM_019813 XM_006517305

OMIM

CCDS

CCDS36677 CCDS49273 CCDS49274

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas