InnateDB Protein
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IDBP-261352.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dbn1
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Protein Name
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drebrin 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000105549
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InnateDB Gene
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IDBG-155945 (Dbn1)
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Protein Structure
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Function |
Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell junction {ECO:0000250}. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in brain. Also present in stomach and to a lesser degree in kidney, colon, and urinary bladder. The E2 isoform is specifically expressed in adult stomach, kidney, and cultured cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
50 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1931838
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InterPro |
IPR002108
Actin-depolymerising factor homology domain
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PFAM |
PF00241
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PRINTS |
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PIRSF |
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SMART |
SM00102
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TIGRFAMs |
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Modification |
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SwissProt |
Q9QXS6
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PhosphoSite |
PhosphoSite-Q9QXS6
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TrEMBL |
Q3TRK3
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UniProt Splice Variant |
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Entrez Gene |
56320
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UniGene |
Mm.19016
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RefSeq |
NP_062787
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MGI ID |
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MGI Symbol |
Dbn1
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OMIM |
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CCDS |
CCDS36677
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HPRD |
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IMGT |
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EMBL |
AB028740
AB064321
AF187147
AF187148
AK132060
AK162697
BC006714
CT009762
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GenPept |
AAF25189
AAF25190
AAH06714
BAB86904
BAB87811
BAE20965
BAE37026
CAM17636
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