Version 5.4
Mus musculus Gene: Aox1
Summary
InnateDB Gene IDBG-156010.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aox1
Gene Name aldehyde oxidase 1
Synonyms AI196512; AI255253; Ao; Aox-1; Aox-2; Aox2; Moro; Ro
Species Mus musculus
Ensembl Gene ENSMUSG00000063558
Encoded Proteins
IDBP-156012
aldehyde oxidase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138356:
Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:58029931-58106413
Strand Forward strand
Band C1.3
Transcripts
ENSMUST00000001027 ENSMUSP00000001027
ENSMUST00000160168
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004031 aldehyde oxidase activity
GO:0005506 iron ion binding
GO:0008762 UDP-N-acetylmuramate dehydrogenase activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0043546 molybdopterin cofactor binding
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0051287 NAD binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138356
View Gene Order
ENSBTAG00000009725
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00760
Nicotinate and nicotinamide metabolism pathway
mmu00830
Retinol metabolism pathway
mmu00750
Vitamin B6 metabolism pathway
mmu00350
Tyrosine metabolism pathway
mmu00280
Valine, leucine and isoleucine degradation pathway
mmu00380
Tryptophan metabolism pathway
mmu00982
Drug metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25012
Vitamins B6 activation to pyridoxal phosphate pathway
REACT_169312
Defective HLCS causes multiple carboxylase deficiency pathway
REACT_169313
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_169316
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_169120
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_11238
Metabolism of water-soluble vitamins and cofactors pathway
REACT_169280
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_169149
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_169363
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_169178
Defective CD320 causes methylmalonic aciduria pathway
REACT_169429
Defects in cobalamin (B12) metabolism pathway
REACT_169169
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_169238
Defects in biotin (Btn) metabolism pathway
REACT_169403
Defective BTD causes biotidinase deficiency pathway
REACT_169415
Defective GIF causes intrinsic factor deficiency pathway
REACT_169385
Defects in vitamin and cofactor metabolism pathway
REACT_169132
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_169256
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_169439
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_111217
Metabolism pathway
REACT_169318
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_116125
Disease pathway
REACT_11193
Metabolism of vitamins and cofactors pathway
KEGG
hsa00750
Vitamin B6 metabolism pathway
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00760
Nicotinate and nicotinamide metabolism pathway
hsa00380
Tryptophan metabolism pathway
hsa00830
Retinol metabolism pathway
hsa00350
Tyrosine metabolism pathway
hsa00982
Drug metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
INOH website
Vitamin B6 metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL G3X8P9
UniProt Splice Variant
Entrez Gene 11761
UniGene Mm.26787
RefSeq NM_009676
OMIM
CCDS CCDS35575
HPRD
IMGT
MGI ID MGI:88035
MGI Symbol Aox1
EMBL AC025116 AC110735 AC117562 CH466548
GenPept EDL00067
RNA Seq Atlas 11761

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca