Version 5.4
Mus musculus Gene: Tlr11
Summary
InnateDB Gene IDBG-156030.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tlr11
Gene Name toll-like receptor 11
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000051969
Encoded Proteins
IDBP-156032
toll-like receptor 11
IDBP-789704
toll-like receptor 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19801549
Tlr11 expression in epithelial cells is regulated by epithelium-specific Ets factors, ELF3 (ESE-1), EHF (ESE-3), via its Ets element and by IRF8 through its IRF motif.
PMID 21097503
Tlr11 is an intracellular receptor in the endoplasmic reticulum, and acts as an innate sensor for Toxoplasma protein profilin.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:50357914-50363663
Strand Forward strand
Band C1
Transcripts
ENSMUST00000063570 ENSMUSP00000068906
ENSMUST00000185091 ENSMUSP00000138814
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 1 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0009617 response to bacterium
GO:0034170 toll-like receptor 11 signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0050707 regulation of cytokine secretion
GO:0050729 positive regulation of inflammatory response
Cellular Component
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_230745
Immune System pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
KEGG
mmu05145
Toxoplasmosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_205819
OMIM
CCDS CCDS27012
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca