Version 5.4
Mus musculus Gene: Pappa
Summary
InnateDB Gene IDBG-156116.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pappa
Gene Name pregnancy-associated plasma protein A
Synonyms 8430414N03Rik; IGFBP-4ase; PAG1; PAPP-A
Species Mus musculus
Ensembl Gene ENSMUSG00000028370
Encoded Proteins
IDBP-156118
pregnancy-associated plasma protein A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182752:
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:65124174-65357509
Strand Forward strand
Band C1
Transcripts
ENSMUST00000084501 ENSMUSP00000081545
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0030154 cell differentiation
GO:0032354 response to follicle-stimulating hormone
GO:0051384 response to glucocorticoid
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000182752
View Gene Order
ENSBTAG00000004010
Not yet available
Pathways
NETPATH
REACTOME
REACT_247926
Metabolism of proteins pathway
REACT_235886
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8R4K8
TrEMBL
UniProt Splice Variant
Entrez Gene 18491
UniGene Mm.317854
RefSeq NM_021362 XM_006537672
OMIM
CCDS CCDS18267
HPRD
IMGT
MGI ID MGI:97479
MGI Symbol Pappa
EMBL AF258461 AF260433 AF439513 AF439514 AF510317 AL691454 AL691491
GenPept AAF70319 AAG09799 AAM12687 AAM12688 AAM44048 CAD62274 CAD83034
RNA Seq Atlas 18491

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca