InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pappa

Summary

InnateDB Protein

IDBP-156118.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pappa

Protein Name

pregnancy-associated plasma protein A

Synonyms

8430414N03Rik; IGFBP-4ase; PAG1; PAPP-A;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081545

InnateDB Gene

IDBG-156116 (Pappa)

Protein Structure

UniProt Annotation

Function

Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected. {ECO:0000269PubMed:11985604}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Detected in kidney, spleen, brain, ovary, breast, skin, prostate, uterus, and placenta. {ECO:0000269PubMed:11956166, ECO:0000269PubMed:11985604}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0030154	cell differentiation
GO:0032354	response to follicle-stimulating hormone
GO:0051384	response to glucocorticoid

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:97479

InterPro

IPR000436 Sushi/SCR/CCP
IPR000800 Notch domain
IPR003961 Fibronectin, type III
IPR006558 LamG-like jellyroll fold
IPR008754 Peptidase M43, pregnancy-associated plasma-A
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR011936 Myxococcus cysteine-rich repeat

PFAM

PF00084
PF00066
PF00041
PF01108
PF05572
PF13948

PRINTS

PR01452

PIRSF

SMART

SM00032
SM00004
SM00060
SM00560

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt