InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp1a3

Summary

InnateDB Gene

IDBG-156172.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp1a3

Gene Name

ATPase, Na+/K+ transporting, alpha 3 polypeptide

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040907

Encoded Proteins

IDBP-156174

ATPase, Na+/K+ transporting, alpha 3 polypeptide

IDBP-156176

ATPase, Na+/K+ transporting, alpha 3 polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105409:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:24978167-25005957

Strand

Reverse strand

Band

Transcripts

ENSMUST00000102858	ENSMUSP00000099922
ENSMUST00000080882	ENSMUSP00000079691
ENSMUST00000146595
ENSMUST00000154077
ENSMUST00000125444

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0031748	D1 dopamine receptor binding
GO:0046872	metal ion binding

Biological Process

GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0007613	memory
GO:0008344	adult locomotory behavior
GO:0008542	visual learning
GO:0015672	monovalent inorganic cation transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035725	sodium ion transmembrane transport
GO:0042493	response to drug

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043209	myelin sheath
GO:0044326	dendritic spine neck
GO:0044327	dendritic spine head
GO:0045202	synapse