Version 5.4
Homo sapiens Gene: ATP1A3
Summary
InnateDB Gene IDBG-53554.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP1A3
Gene Name ATPase, Na+/K+ transporting, alpha 3 polypeptide
Synonyms AHC2; DYT12; RDP
Species Homo sapiens
Ensembl Gene ENSG00000105409
Encoded Proteins
IDBP-53556
ATPase, Na+/K+ transporting, alpha 3 polypeptide
IDBP-380910
ATPase, Na+/K+ transporting, alpha 3 polypeptide
IDBP-762013
IDBP-591838
ATPase, Na+/K+ transporting, alpha 3 polypeptide
IDBP-597063
ATPase, Na+/K+ transporting, alpha 3 polypeptide
IDBP-766087
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:41966582-41997497
Strand Reverse strand
Band q13.2
Transcripts
ENST00000302102 ENSP00000302397
ENST00000441343 ENSP00000411503
ENST00000485672
ENST00000473086 ENSP00000469129
ENST00000468774
ENST00000465007
ENST00000545399 ENSP00000444688
ENST00000543770 ENSP00000437577
ENST00000602133 ENSP00000471581
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005391 sodium:potassium-exchanging ATPase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829 cation-transporting ATPase activity
GO:0031748 D1 dopamine receptor binding
GO:0046872 metal ion binding
Biological Process
GO:0006754 ATP biosynthetic process
GO:0006812 cation transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0007613 memory
GO:0008344 adult locomotory behavior
GO:0008542 visual learning
GO:0015672 monovalent inorganic cation transport
GO:0034220 ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035725 sodium ion transmembrane transport
GO:0042493 response to drug
GO:0055085 transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0043209 myelin sheath
GO:0044326 dendritic spine neck
GO:0044327 dendritic spine head
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040907
View Gene Order
ENSBTAG00000018635
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_25149
Ion transport by P-type ATPases pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
hsa04260
Cardiac muscle contraction pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
hsa04971
Gastric acid secretion pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
hsa04976
Bile secretion pathway
hsa04974
Protein digestion and absorption pathway
hsa04973
Carbohydrate digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.515427 Hs.632922 Hs.709141
RefSeq NM_001256213 NM_001256214 NM_152296
HUGO
OMIM
CCDS CCDS12594 CCDS58663 CCDS58664
HPRD 01666
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca