InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grik5

Summary

InnateDB Gene

IDBG-156201.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grik5

Gene Name

glutamate receptor, ionotropic, kainate 5 (gamma 2)

Synonyms

GluK5; GluRgamma2; KA2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003378

Encoded Proteins

IDBP-156203

glutamate receptor, ionotropic, kainate 5 (gamma 2)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105737:
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. [provided by RefSeq, Jul 2008]
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:25009853-25072369

Strand

Reverse strand

Band

Transcripts

ENSMUST00000003468

ENSMUSP00000003468

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity
GO:0015277	kainate selective glutamate receptor activity
GO:0017124	SH3 domain binding
GO:0030165	PDZ domain binding
GO:0042802	identical protein binding

Biological Process

GO:0006621	protein retention in ER lumen
GO:0006810	transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0031630	regulation of synaptic vesicle fusion to presynaptic membrane
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042391	regulation of membrane potential
GO:0043113	receptor clustering
GO:0043525	positive regulation of neuron apoptotic process
GO:0051649	establishment of localization in cell
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0071333	cellular response to glucose stimulus

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0008328	ionotropic glutamate receptor complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0032983	kainate selective glutamate receptor complex
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043204	perikaryon
GO:0045211	postsynaptic membrane