Version 5.4
Homo sapiens Gene: GRIK5
Summary
InnateDB Gene IDBG-53644.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRIK5
Gene Name glutamate receptor, ionotropic, kainate 5
Synonyms EAA2; GluK5; GRIK2; KA2
Species Homo sapiens
Ensembl Gene ENSG00000105737
Encoded Proteins
IDBP-53646
glutamate receptor, ionotropic, kainate 5
IDBP-53648
glutamate receptor, ionotropic, kainate 5
IDBP-763543
IDBP-765457
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. [provided by RefSeq, Jul 2008]
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:41998321-42069498
Strand Reverse strand
Band q13.2
Transcripts
ENST00000262895 ENSP00000262895
ENST00000301218 ENSP00000301218
ENST00000454993
ENST00000594528 ENSP00000469135
ENST00000593562 ENSP00000470251
ENST00000602210
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004970 ionotropic glutamate receptor activity
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005515 protein binding
GO:0008066 glutamate receptor activity
GO:0015277 kainate selective glutamate receptor activity
GO:0017124 SH3 domain binding
GO:0030165 PDZ domain binding
GO:0042802 identical protein binding
Biological Process
GO:0006621 protein retention in ER lumen
GO:0006810 transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane
GO:0034220 ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0042391 regulation of membrane potential
GO:0043113 receptor clustering
GO:0043525 positive regulation of neuron apoptotic process
GO:0051649 establishment of localization in cell
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0071333 cellular response to glucose stimulus
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0008328 ionotropic glutamate receptor complex
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0032983 kainate selective glutamate receptor complex
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043204 perikaryon
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003378
View Gene Order
ENSBTAG00000011723
Not yet available
Pathways
NETPATH
REACTOME
REACT_13685
Neuronal System pathway
REACT_21322
Ionotropic activity of Kainate Receptors pathway
REACT_21312
Activation of Kainate Receptors upon glutamate binding pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_21346
Activation of Ca-permeable Kainate Receptor pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.367799
RefSeq NM_001301030 NM_002088 XM_005258821 XM_006723169 XM_006723170
HUGO
OMIM
CCDS CCDS12595
HPRD 02614
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca