InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hmgb2

Summary

InnateDB Gene

IDBG-156235.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmgb2

Gene Name

high mobility group box 2

Synonyms

C80539; HMG-2; Hmg2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000054717

Encoded Proteins

IDBP-156237

high mobility group box 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19890330

[Homo sapiens] HMGB2 functions as a universal sentinel for nucleic-acid-mediated innate immune responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164104:
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:57511843-57515999

Strand

Forward strand

Band

Transcripts

ENSMUST00000067925

ENSMUSP00000065940

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008301	DNA binding, bending
GO:0019904	protein domain specific binding
GO:0042056	chemoattractant activity
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding
GO:0050786	RAGE receptor binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0006288	base-excision repair, DNA ligation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007283	spermatogenesis
GO:0007289	spermatid nucleus differentiation
GO:0008584	male gonad development
GO:0032075	positive regulation of nuclease activity
GO:0043388	positive regulation of DNA binding
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048545	response to steroid hormone
GO:0050918	positive chemotaxis
GO:0060326	cell chemotaxis
GO:0071222	cellular response to lipopolysaccharide
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0000793	condensed chromosome
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm