InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HMGB2

Summary

InnateDB Gene

IDBG-44657.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGB2

Gene Name

high mobility group box 2

Synonyms

HMG2

Species

Homo sapiens

Ensembl Gene

ENSG00000164104

Encoded Proteins

IDBP-44659

high mobility group box 2

IDBP-379780

high mobility group box 2

IDBP-379781

high mobility group box 2

IDBP-481566

high mobility group box 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19890330

HMGB2 functions as a universal sentinel for nucleic-acid-mediated innate immune responses.

Entrez Gene

Summary

This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:173331695-173335125

Strand

Reverse strand

Band

q34.1

Transcripts

ENST00000296503	ENSP00000296503
ENST00000446922	ENSP00000393448
ENST00000438704	ENSP00000404912
ENST00000511316
ENST00000506267	ENSP00000423001

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	30 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008301	DNA binding, bending
GO:0019904	protein domain specific binding
GO:0042056	chemoattractant activity
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding
GO:0050786	RAGE receptor binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0006265	DNA topological change
GO:0006288	base-excision repair, DNA ligation
GO:0006309	apoptotic DNA fragmentation
GO:0006325	chromatin organization
GO:0006334	nucleosome assembly
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007283	spermatogenesis
GO:0007289	spermatid nucleus differentiation
GO:0008584	male gonad development
GO:0032075	positive regulation of nuclease activity
GO:0033151	V(D)J recombination
GO:0043388	positive regulation of DNA binding
GO:0045087	innate immune response (InnateDB)
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048545	response to steroid hormone
GO:0050918	positive chemotaxis
GO:0051103	DNA ligation involved in DNA repair
GO:0060326	cell chemotaxis
GO:0071222	cellular response to lipopolysaccharide
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0000793	condensed chromosome
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000054717

View Gene Order

ENSBTAG00000015101

Not yet available

Pathways

NETPATH

REACTOME

REACT_13462

Activation of DNA fragmentation factor pathway

REACT_995

Apoptotic execution phase pathway

REACT_1213

Apoptosis induced DNA fragmentation pathway

REACT_578

Apoptosis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P26583

TrEMBL

D6R9A6 Q5U071

UniProt Splice Variant

Entrez Gene

3148

UniGene

RefSeq

NM_001130689 NM_001130688 NM_002129

HUGO

HGNC:5000

OMIM

163906

CCDS

CCDS3816

HPRD

01229

IMGT

EMBL

AC097534 AK311864 BC001063 BC100019 BT019782 BT019783 CH471056 M83665 X62534 Z17240

GenPept

AAA58659 AAH01063 AAI00020 AAV38585 AAV38586 BAG34805 CAA44395 CAA78938 EAX04758 EAX04759

RNA Seq Atlas

3148