Version 5.4
Mus musculus Gene: Aifm2
Summary
InnateDB Gene IDBG-156262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aifm2
Gene Name apoptosis-inducing factor, mitochondrion-associated 2
Synonyms 5430437E11Rik; Amid; D730001I10Rik; PRG3
Species Mus musculus
Ensembl Gene ENSMUSG00000020085
Encoded Proteins
IDBP-156264
apoptosis-inducing factor, mitochondrion-associated 2
IDBP-156266
apoptosis-inducing factor, mitochondrion-associated 2
IDBP-156268
apoptosis-inducing factor, mitochondrion-associated 2
IDBP-270846
apoptosis-inducing factor, mitochondrion-associated 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000042286:
This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:61715263-61739260
Strand Forward strand
Band B4
Transcripts
ENSMUST00000099706 ENSMUSP00000097297
ENSMUST00000067857 ENSMUSP00000070054
ENSMUST00000080099 ENSMUSP00000078998
ENSMUST00000105455 ENSMUSP00000101095
ENSMUST00000131361
ENSMUST00000129809
ENSMUST00000140664
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004174 electron-transferring-flavoprotein dehydrogenase activity
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0008637 apoptotic mitochondrial changes
GO:0030261 chromosome condensation
GO:0043065 positive regulation of apoptotic process
GO:0055114 oxidation-reduction process
GO:0097194 execution phase of apoptosis
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000042286
View Gene Order
ENSBTAG00000001165
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt Q8BUE4
TrEMBL
UniProt Splice Variant
Entrez Gene 71361
UniGene Mm.286309
RefSeq NM_001039194 NM_001284300 NM_153779 NM_178058 XM_006514121 XM_006514122 XM_006514123 XM_006514124 XM_006514125 XM_006514126 XM_006514127 XM_006514128
OMIM
CCDS CCDS23884 CCDS48576
HPRD
IMGT
MGI ID MGI:1918611
MGI Symbol Aifm2
EMBL AC153136 AK085656 AK147741 AK155240 BC038129
GenPept AAH38129 BAC39497 BAE28108 BAE33142
RNA Seq Atlas 71361

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca