Version 5.4
Homo sapiens Gene: AIFM2
Summary
InnateDB Gene IDBG-77220.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AIFM2
Gene Name apoptosis-inducing factor, mitochondrion-associated, 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000042286
Encoded Proteins
IDBP-77222
apoptosis-inducing factor, mitochondrion-associated, 2
IDBP-77224
apoptosis-inducing factor, mitochondrion-associated, 2
IDBP-810533
apoptosis-inducing factor, mitochondrion-associated, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:70098223-70132934
Strand Reverse strand
Band q22.1
Transcripts
ENST00000373248 ENSP00000362345
ENST00000307864 ENSP00000312370
ENST00000482166
ENST00000613322 ENSP00000478931
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004174 electron-transferring-flavoprotein dehydrogenase activity
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0008637 apoptotic mitochondrial changes
GO:0043065 positive regulation of apoptotic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020085
View Gene Order
ENSBTAG00000001165
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.650680 Hs.655377 Hs.682313
RefSeq NM_001198696 NM_032797
HUGO
OMIM
CCDS CCDS7297
HPRD 09797
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca