Version 5.4
| Homo sapiens Gene: TDP1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-15629.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | TDP1 | ||||||||||||||||||
| Gene Name | tyrosyl-DNA phosphodiesterase 1 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000042088 | ||||||||||||||||||
| Encoded Proteins |
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 14:89954939-90044768 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q32.11 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Processing of DNA ends prior to end rejoining pathway
Nonhomologous End-joining (NHEJ) pathway
Double-Strand Break Repair pathway
DNA Repair pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | G3V2F4 G3V2J6 G3V2U6 G3V3Q0 G3V554 G3V5B8 G3V5F9 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 55775 | ||||||||||||||||||
| UniGene | Hs.209945 | ||||||||||||||||||
| RefSeq | NM_001008744 NM_018319 XM_005267847 XM_005267848 XM_006720197 XM_006720198 XM_006720199 XM_006720200 XM_006720201 | ||||||||||||||||||
| HUGO | HGNC:18884 | ||||||||||||||||||
| OMIM | 607198 | ||||||||||||||||||
| CCDS | CCDS9888 | ||||||||||||||||||
| HPRD | 06226 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AL137128 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 55775 | ||||||||||||||||||