InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ddx46

Summary

InnateDB Gene

IDBG-156566.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx46

Gene Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 46

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021500

Encoded Proteins

IDBP-156568

DEAD (Asp-Glu-Ala-Asp) box polypeptide 46

IDBP-622690

DEAD (Asp-Glu-Ala-Asp) box polypeptide 46

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145833:
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:55635027-55681256

Strand

Forward strand

Band

Transcripts

ENSMUST00000099479	ENSMUSP00000097078
ENSMUST00000172272	ENSMUSP00000133245

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006397	mRNA processing
GO:0008152	metabolic process
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0015030	Cajal body
GO:0016607	nuclear speck

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000145833

View Gene Order

ENSBTAG00000021520

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu03040

Spliceosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

Q569Z5

TrEMBL

F8WHR6 Q3UUW9 Q9CVD6

UniProt Splice Variant

Entrez Gene

212880

UniGene

Mm.202725 Mm.392552 Mm.474698

RefSeq

NM_001282055 NM_145975 XM_006517202 XM_006517203

OMIM

CCDS

CCDS70464

HPRD

IMGT

MGI ID

MGI:1920895

MGI Symbol

Ddx46

EMBL

AC126408 AK008639 AK129220 AK137835 BC026492 BC092240

GenPept

AAH26492 AAH92240 BAB25800 BAC98030 BAE23504

RNA Seq Atlas

212880