Version 5.4
Mus musculus Protein: Ddx46
Summary
InnateDB Protein IDBP-622690.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ddx46
Protein Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000133245
InnateDB Gene IDBG-156566 (Ddx46)
Protein Structure
UniProt Annotation
Function Plays an essential role in splicing, either prior to, or during A complex formation. {ECO:0000250}.
Subcellular Localization Nucleus speckle {ECO:0000250}. Nucleus, Cajal body {ECO:0000250}. Note=Present in Cajal bodies (CBs) and nuclear speckles. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0015030 Cajal body
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID MGI:1920895
InterPro IPR001650 Helicase, C-terminal
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00271
PF00270
PRINTS
PIRSF
SMART SM00490
SM00487
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q569Z5
PhosphoSite PhosphoSite-Q569Z5
TrEMBL Q9CVD6
UniProt Splice Variant
Entrez Gene 212880
UniGene Mm.474698
RefSeq NP_001268984
MGI ID
MGI Symbol Ddx46
OMIM
CCDS CCDS70464
HPRD
IMGT
EMBL AK008639 AK129220 AK137835 BC026492 BC092240
GenPept AAH26492 AAH92240 BAB25800 BAC98030 BAE23504

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca