Mus musculus Gene: Adra2c | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-156745.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Adra2c | ||||||||||||||||||||||
Gene Name | adrenergic receptor, alpha 2c | ||||||||||||||||||||||
Synonyms | [a]2C; Adra-2c; alpha2-C4; alpha2C | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000045318 | ||||||||||||||||||||||
Encoded Proteins |
adrenergic receptor, alpha 2c
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184160:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:35278566-35281761 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | B2 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Adrenoceptors pathway
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Amine ligand-binding receptors pathway
Integration of energy metabolism pathway
Metabolism pathway
Platelet activation, signaling and aggregation pathway
Regulation of insulin secretion pathway
GPCR ligand binding pathway
G alpha (z) signalling events pathway
G alpha (i) signalling events pathway
Signal Transduction pathway
Platelet Aggregation (Plug Formation) pathway
Adrenaline signalling through Alpha-2 adrenergic receptor pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
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KEGG |
Neuroactive ligand-receptor interaction pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Adrenaline signalling through Alpha-2 adrenergic receptor pathway
Platelet Aggregation (Plug Formation) pathway
G alpha (i) signalling events pathway
G alpha (z) signalling events pathway
Adrenoceptors pathway
Amine ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
Regulation of insulin secretion pathway
Integration of energy metabolism pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Metabolism pathway
Hemostasis pathway
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KEGG |
Neuroactive ligand-receptor interaction pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.57205 | ||||||||||||||||||||||
RefSeq | NM_007418 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS19226 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||