InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adra2c

Summary

InnateDB Protein

IDBP-156747.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adra2c

Protein Name

adrenergic receptor, alpha 2c

Synonyms

[a]2C; Adra-2c; alpha2-C4; alpha2C;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059705

InnateDB Gene

IDBG-156745 (Adra2c)

Protein Structure

UniProt Annotation

Function

Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004938	alpha2-adrenergic receptor activity
GO:0005515	protein binding
GO:0031694	alpha-2A adrenergic receptor binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051379	epinephrine binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007565	female pregnancy
GO:0030168	platelet activation
GO:0032148	activation of protein kinase B activity
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0045666	positive regulation of neuron differentiation
GO:0045907	positive regulation of vasoconstriction
GO:0051930	regulation of sensory perception of pain
GO:0070473	negative regulation of uterine smooth muscle contraction
GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043679	axon terminus

Protein Structure and Domains

PDB ID

MGI:87936

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000735 Alpha 2C adrenoceptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00560
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q01337