Version 5.4
Mus musculus Gene: Orc2
Summary
InnateDB Gene IDBG-156912.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Orc2
Gene Name origin recognition complex, subunit 2
Synonyms AU041563; Orc2l
Species Mus musculus
Ensembl Gene ENSMUSG00000026037
Encoded Proteins
IDBP-156914
origin recognition complex, subunit 2
IDBP-251995
origin recognition complex, subunit 2
IDBP-790165
origin recognition complex, subunit 2
IDBP-790167
origin recognition complex, subunit 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115942:
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:58462771-58505109
Strand Reverse strand
Band C1.3
Transcripts
ENSMUST00000027198 ENSMUSP00000027198
ENSMUST00000114325 ENSMUSP00000109964
ENSMUST00000151723
ENSMUST00000190695 ENSMUSP00000139869
ENSMUST00000191206 ENSMUSP00000141138
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
Biological Process
GO:0006260 DNA replication
Cellular Component
GO:0000785 chromatin
GO:0000792 heterochromatin
GO:0000808 origin recognition complex
GO:0000939 condensed chromosome inner kinetochore
GO:0005634 nucleus
GO:0005664 nuclear origin of replication recognition complex
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115942
View Gene Order
ENSBTAG00000031473
Not yet available
Pathways
NETPATH
REACTOME
REACT_247969
Assembly of the ORC complex at the origin of replication pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_258062
Synthesis of DNA pathway
REACT_244558
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_232628
DNA Replication pathway
REACT_262530
Switching of origins to a post-replicative state pathway
REACT_188804
Cell Cycle pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_259974
CDC6 association with the ORC:origin complex pathway
REACT_255479
Regulation of DNA replication pathway
REACT_254983
Activation of the pre-replicative complex pathway
REACT_245230
Orc1 removal from chromatin pathway
REACT_245528
M/G1 Transition pathway
REACT_235397
G2/M Checkpoints pathway
REACT_204269
E2F-enabled inhibition of pre-replication complex formation pathway
REACT_262002
Association of licensing factors with the pre-replicative complex pathway
REACT_253002
G1/S Transition pathway
REACT_236939
Removal of licensing factors from origins pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_232236
Activation of ATR in response to replication stress pathway
REACT_206830
E2F mediated regulation of DNA replication pathway
REACT_235483
DNA Replication Pre-Initiation pathway
REACT_230841
Assembly of the pre-replicative complex pathway
REACT_253623
S Phase pathway
KEGG
mmu04110
Cell cycle pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_1181
Association of licensing factors with the pre-replicative complex pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_1707
CDC6 association with the ORC:origin complex pathway
REACT_1949
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_567
Assembly of the ORC complex at the origin of replication pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_1321
E2F-enabled inhibition of pre-replication complex formation pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_829
Regulation of DNA replication pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04110
Cell cycle pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001025378 NM_001271526 NM_008765 XM_006495775
OMIM
CCDS CCDS14974 CCDS14975
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca