InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Orc2

Summary

InnateDB Protein

IDBP-156914.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Orc2

Protein Name

origin recognition complex, subunit 2

Synonyms

AU041563; Orc2l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027198

InnateDB Gene

IDBG-156912 (Orc2)

Protein Structure

UniProt Annotation

Function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003688	DNA replication origin binding
GO:0005515	protein binding

Biological Process

GO:0006260

DNA replication

Cellular Component

GO:0000785	chromatin
GO:0000792	heterochromatin
GO:0000808	origin recognition complex
GO:0000939	condensed chromosome inner kinetochore
GO:0005634	nucleus
GO:0005664	nuclear origin of replication recognition complex
GO:0005886	plasma membrane
GO:0016020	membrane