Version 5.4
Homo sapiens Gene: DCTN6
Summary
InnateDB Gene IDBG-15710.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCTN6
Gene Name dynactin 6
Synonyms p27; WS-3; WS3
Species Homo sapiens
Ensembl Gene ENSG00000104671
Encoded Proteins
IDBP-15712
dynactin 6
IDBP-481221
dynactin 6
IDBP-476481
dynactin 6
IDBP-478873
dynactin 6
IDBP-483327
dynactin 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:30156297-30183640
Strand Forward strand
Band p12
Transcripts
ENST00000221114 ENSP00000221114
ENST00000522141 ENSP00000430109
ENST00000522540
ENST00000520829 ENSP00000431017
ENST00000523666 ENSP00000427955
ENST00000519830 ENSP00000429408
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0045502 dynein binding
Biological Process
GO:0007052 mitotic spindle organization
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005869 dynactin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031516
View Gene Order
ENSBTAG00000000744
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04962
Vasopressin-regulated water reabsorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.158427
RefSeq NM_006571
HUGO
OMIM
CCDS CCDS6076
HPRD 09907
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca