Version 5.4
Mus musculus Gene: Pdcd1lg2
Summary
InnateDB Gene IDBG-157298.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pdcd1lg2
Gene Name programmed cell death 1 ligand 2
Synonyms B7-DC; Btdc; F730015O22Rik; PD-L2
Species Mus musculus
Ensembl Gene ENSMUSG00000016498
Encoded Proteins
IDBP-255718
programmed cell death 1 ligand 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21097698
[Homo sapiens] PDCD1LG2 expression in macrophages is induced upon exposure to HIV virions, and is transcriptionally down-regulated by IL10.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197646:
Gene Information
Type Protein coding
Genomic Location Chromosome 19:29410919-29471157
Strand Forward strand
Band C1
Transcripts
ENSMUST00000112576 ENSMUSP00000108195
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0042102 positive regulation of T cell proliferation
GO:0042130 negative regulation of T cell proliferation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000197646
View Gene Order
ENSBTAG00000033316
Not yet available
Pathways
NETPATH
REACTOME
REACT_263643
PD-1 signaling pathway
REACT_230745
Immune System pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19324
PD-1 signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt Q9WUL5
TrEMBL Q3U304
UniProt Splice Variant
Entrez Gene 58205
UniGene Mm.116737
RefSeq NM_021396
OMIM
CCDS CCDS29736
HPRD
IMGT
MGI ID MGI:1930125
MGI Symbol Pdcd1lg2
EMBL AF142780 AK089369 AK141111 AK155002 BC104138 BC104139 CH466534
GenPept AAD33892 AAI04139 AAI04140 BAC40858 BAE24564 BAE32986 EDL41683
RNA Seq Atlas 58205

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca