Version 5.4
Mus musculus Protein: Pdcd1lg2
Summary
InnateDB Protein IDBP-255718.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pdcd1lg2
Protein Name programmed cell death 1 ligand 2
Synonyms B7-DC; Btdc; F730015O22Rik; PD-L2;
Species Mus musculus
Ensembl Protein ENSMUSP00000108195
InnateDB Gene IDBG-157298 (Pdcd1lg2)
Protein Structure
UniProt Annotation
Function Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. {ECO:0000269PubMed:11224527, ECO:0000269PubMed:11283156, ECO:0000269PubMed:12719480}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in immature and mature bone marrow- derived dendritic cells and splenic dendritic cells. Highly expressed in placenta, liver and weakly expressed in heart, spleen, lymph nodes and thymus. Also expressed in some tumor cell lines of lymphoid origin. {ECO:0000269PubMed:11224527, ECO:0000269PubMed:11283156}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0042102 positive regulation of T cell proliferation
GO:0042130 negative regulation of T cell proliferation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1930125
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013162 CD80-like, immunoglobulin C2-set
PFAM PF08205
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WUL5
PhosphoSite PhosphoSite-
TrEMBL Q3U304
UniProt Splice Variant
Entrez Gene 58205
UniGene Mm.116737
RefSeq NP_067371
MGI ID 3RNQ
MGI Symbol Pdcd1lg2
OMIM
CCDS CCDS29736
HPRD
IMGT
EMBL AF142780 AK089369 AK141111 AK155002 BC104138 BC104139 CH466534
GenPept AAD33892 AAI04139 AAI04140 BAC40858 BAE24564 BAE32986 EDL41683

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca