Version 5.4
Mus musculus Gene: Tle1
Summary
InnateDB Gene IDBG-157429.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tle1
Gene Name transducin-like enhancer of split 1, homolog of Drosophila E(spl)
Synonyms C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l
Species Mus musculus
Ensembl Gene ENSMUSG00000008305
Encoded Proteins
IDBP-157431
transducin-like enhancer of split 1, homolog of Drosophila E(spl)
IDBP-157433
transducin-like enhancer of split 1, homolog of Drosophila E(spl)
IDBP-157435
transducin-like enhancer of split 1, homolog of Drosophila E(spl)
IDBP-157437
transducin-like enhancer of split 1, homolog of Drosophila E(spl)
IDBP-266847
transducin-like enhancer of split 1, homolog of Drosophila E(spl)
IDBP-533901
transducin-like enhancer of split 1, homolog of Drosophila E(spl)
IDBP-542645
transducin-like enhancer of split 1, homolog of Drosophila E(spl)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196781:
Gene Information
Type Protein coding
Genomic Location Chromosome 4:72117142-72200919
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000030095 ENSMUSP00000030095
ENSMUST00000072695 ENSMUSP00000072481
ENSMUST00000102848 ENSMUSP00000099912
ENSMUST00000074216 ENSMUSP00000073839
ENSMUST00000107337 ENSMUSP00000102960
ENSMUST00000132550
ENSMUST00000123259
ENSMUST00000140154 ENSMUSP00000118513
ENSMUST00000137075 ENSMUSP00000118683
ENSMUST00000134225
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 17 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 96 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0010628 positive regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045892 negative regulation of transcription, DNA-templated
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000196781
View Gene Order
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_258066
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_203336
Degradation of beta-catenin by the destruction complex pathway
REACT_233471
repression of WNT target genes pathway
REACT_235529
AMER1 mutants destabilize the destruction complex pathway
REACT_231507
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_258576
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_219771
deactivation of the beta-catenin transactivating complex pathway
REACT_216539
formation of the beta-catenin:TCF transactivating complex pathway
REACT_230286
APC truncation mutants have impaired AXIN binding pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_241514
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_236203
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_234076
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_252458
AXIN missense mutants destabilize the destruction complex pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_263691
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_248000
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_261276
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_254498
TCF7L2 mutants don't bind CTBP pathway
REACT_250714
truncations of AMER1 destabilize the destruction complex pathway
REACT_196464
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_188257
Signal Transduction pathway
REACT_237096
truncated APC mutants destabilize the destruction complex pathway
REACT_231152
Signaling by NOTCH pathway
REACT_260752
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
INOH
INOH website
Wnt signaling pathway pathway
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_228106
repression of WNT target genes pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
Wnt signaling pathway pathway
INOH website
TGF-beta signaling pathway
PID NCI
ps1pathway
Presenilin action in Notch and Wnt signaling
hes_heypathway
Notch-mediated HES/HEY network
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt
TrEMBL Q5SQA7
UniProt Splice Variant
Entrez Gene 21885
UniGene Mm.278444 Mm.404851
RefSeq NM_001285529 NM_001285531 NM_001285532 NM_011599 XM_006537758 XM_006537759 XM_006537760 XM_006537761 XM_006537763 XM_006537765 XM_006537767
OMIM
CCDS CCDS18274 CCDS71407
HPRD
IMGT
MGI ID MGI:104636
MGI Symbol Tle1
EMBL AL773513 BX640475
GenPept
RNA Seq Atlas 21885

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca