InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tle1

Summary

InnateDB Protein

IDBP-542645.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tle1

Protein Name

transducin-like enhancer of split 1, homolog of Drosophila E(spl)

Synonyms

C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118683

InnateDB Gene

IDBG-157429 (Tle1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	17 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	96 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

MGI:104636

InterPro

IPR005617 Groucho/TLE, N-terminal Q-rich domain

PFAM

PF03920

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q5SQA5

UniProt Splice Variant

Entrez Gene

21885

UniGene

Mm.404851

RefSeq

MGI ID

MGI Symbol

Tle1

OMIM

CCDS

HPRD

IMGT

EMBL

AL773513 BX640475

GenPept