Version 5.4
Mus musculus Gene: Smad5
Summary
InnateDB Gene IDBG-157537.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smad5
Gene Name SMAD family member 5
Synonyms 1110051M15Rik; AI451355; Dwf-C; Madh5; MusMLP
Species Mus musculus
Ensembl Gene ENSMUSG00000021540
Encoded Proteins
IDBP-157539
MAD homolog 5 (Drosophila)
IDBP-261464
MAD homolog 5 (Drosophila)
IDBP-261466
MAD homolog 5 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113658:
The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2011]
The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:56703010-56742377
Strand Forward strand
Band B1
Transcripts
ENSMUST00000069557 ENSMUSP00000065798
ENSMUST00000109876 ENSMUSP00000105502
ENSMUST00000109874 ENSMUSP00000105500
ENSMUST00000138677
ENSMUST00000132302
ENSMUST00000136702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
Biological Process
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001657 ureteric bud development
GO:0001880 Mullerian duct regression
GO:0002051 osteoblast fate commitment
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007281 germ cell development
GO:0009880 embryonic pattern specification
GO:0030218 erythrocyte differentiation
GO:0030509 BMP signaling pathway
GO:0045669 positive regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051216 cartilage development
GO:0060048 cardiac muscle contraction
GO:0060348 bone development
GO:0071407 cellular response to organic cyclic compound
GO:0071773 cellular response to BMP stimulus
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113658
View Gene Order
ENSBTAG00000021772
Not yet available
Pathways
NETPATH
REACTOME
REACT_220505
Signaling by BMP pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04350
TGF-beta signaling pathway pathway
INOH
INOH website
BMP2 signaling pathway
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12034
Signaling by BMP pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
bmppathway
BMP receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.272920
RefSeq NM_001164041 NM_001164042 NM_008541 XM_006517117 XM_006517118 XM_006517119
OMIM
CCDS CCDS26565
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca