Version 5.4
Homo sapiens Gene: SMAD5
Summary
InnateDB Gene IDBG-45903.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMAD5
Gene Name SMAD family member 5
Synonyms DWFC; JV5-1; MADH5
Species Homo sapiens
Ensembl Gene ENSG00000113658
Encoded Proteins
IDBP-474172
SMAD family member 5
IDBP-474566
SMAD family member 5
IDBP-482267
SMAD family member 5
IDBP-473605
SMAD family member 5
IDBP-483048
SMAD family member 5
IDBP-474268
SMAD family member 5
IDBP-482025
SMAD family member 5
IDBP-602303
SMAD family member 5
IDBP-591046
SMAD family member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2011]
The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:136132845-136188747
Strand Forward strand
Band q31.1
Transcripts
ENST00000507118 ENSP00000425749
ENST00000511116 ENSP00000424279
ENST00000509297 ENSP00000426696
ENST00000515005 ENSP00000427330
ENST00000509962
ENST00000506223 ENSP00000422954
ENST00000507245
ENST00000507637 ENSP00000427474
ENST00000514777
ENST00000513418 ENSP00000427650
ENST00000545279 ENSP00000441954
ENST00000545620 ENSP00000446474
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 93 [view]
Protein-Protein 93 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
Biological Process
GO:0001503 ossification
GO:0001657 ureteric bud development
GO:0001880 Mullerian duct regression
GO:0002051 osteoblast fate commitment
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007281 germ cell development
GO:0009880 embryonic pattern specification
GO:0030218 erythrocyte differentiation
GO:0030509 BMP signaling pathway
GO:0035556 intracellular signal transduction
GO:0045669 positive regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051216 cartilage development
GO:0060048 cardiac muscle contraction
GO:0060348 bone development
GO:0071407 cellular response to organic cyclic compound
GO:0071773 cellular response to BMP stimulus
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016021 integral component of membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021540
View Gene Order
ENSBTAG00000021772
Not yet available
Pathways
NETPATH
REACTOME
REACT_12034
Signaling by BMP pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
bmppathway
BMP receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.167700 Hs.601906 Hs.626324 Hs.634760
RefSeq NM_001001419 NM_001001420 NM_005903
HUGO
OMIM
CCDS CCDS75308
HPRD 04381
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca