Version 5.4
Mus musculus Gene: Uhrf2
Summary
InnateDB Gene IDBG-157687.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Uhrf2
Gene Name ubiquitin-like, containing PHD and RING finger domains 2
Synonyms 2310065A22Rik; AI426270; AW214556; D130071B19Rik; Nirf
Species Mus musculus
Ensembl Gene ENSMUSG00000024817
Encoded Proteins
IDBP-157689
ubiquitin-like, containing PHD and RING finger domains 2
IDBP-255758
ubiquitin-like, containing PHD and RING finger domains 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147854:
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:30030513-30093722
Strand Forward strand
Band C1
Transcripts
ENSMUST00000025739 ENSMUSP00000025739
ENSMUST00000112552 ENSMUSP00000108171
ENSMUST00000134518
ENSMUST00000137368
ENSMUST00000129420
ENSMUST00000150532
ENSMUST00000127244
ENSMUST00000123773
ENSMUST00000143769
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042393 histone binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0016567 protein ubiquitination
GO:0030154 cell differentiation
GO:0051865 protein autoubiquitination
GO:0071158 positive regulation of cell cycle arrest
Cellular Component
GO:0005634 nucleus
GO:0005720 nuclear heterochromatin
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000147854
View Gene Order
ENSBTAG00000020815
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.313364
RefSeq NM_144873 XM_006526602
OMIM
CCDS CCDS37955
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca