InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Uhrf2

Summary

InnateDB Protein

IDBP-157689.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Uhrf2

Protein Name

ubiquitin-like, containing PHD and RING finger domains 2

Synonyms

2310065A22Rik; AI426270; AW214556; D130071B19Rik; Nirf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025739

InnateDB Gene

IDBG-157687 (Uhrf2)

Protein Structure

UniProt Annotation

Function

E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131 (By similarity). E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. {ECO:0000250, ECO:0000269PubMed:21598301}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00358, ECO:0000269PubMed:21598301}. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042393	histone binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007049	cell cycle
GO:0008283	cell proliferation
GO:0016567	protein ubiquitination
GO:0030154	cell differentiation
GO:0051865	protein autoubiquitination
GO:0071158	positive regulation of cell cycle arrest

Cellular Component

GO:0005634	nucleus
GO:0005720	nuclear heterochromatin

Protein Structure and Domains

PDB ID

MGI:1923718

InterPro

IPR000626 Ubiquitin-like
IPR001841 Zinc finger, RING-type
IPR001965 Zinc finger, PHD-type
IPR003105 SRA-YDG
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
IPR021991 Domain of unknown function DUF3590
IPR029071 Ubiquitin-related domain

PFAM