InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hnrnpa0

Summary

InnateDB Gene

IDBG-157846.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hnrnpa0

Gene Name

heterogeneous nuclear ribonucleoprotein A0

Synonyms

1110055B05Rik; 3010025E17Rik; hnRNP A0; Hnrpa0

Species

Mus musculus

Ensembl Gene

ENSMUSG00000007836

Encoded Proteins

IDBP-157848

heterogeneous nuclear ribonucleoprotein A0

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177733:
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:58125879-58128556

Strand

Reverse strand

Band

Transcripts

ENSMUST00000007980

ENSMUSP00000007980

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	65 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0017091	AU-rich element binding
GO:0019901	protein kinase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006954	inflammatory response
GO:0032496	response to lipopolysaccharide
GO:0070935	3'-UTR-mediated mRNA stabilization

Cellular Component

GO:0005634	nucleus
GO:0030529	ribonucleoprotein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000177733

View Gene Order

ENSBTAG00000016929

Not yet available

Pathways

NETPATH

REACTOME

REACT_249110

mRNA Splicing pathway

REACT_233572

Gene Expression pathway

REACT_260226

mRNA Splicing - Major Pathway pathway

REACT_233950

Processing of Capped Intron-Containing Pre-mRNA pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9CX86

TrEMBL

UniProt Splice Variant

Entrez Gene

77134

UniGene

Mm.490274

RefSeq

NM_029872

OMIM

CCDS

CCDS49280

HPRD

IMGT

MGI ID

MGI:1924384

MGI Symbol

Hnrnpa0

EMBL

AC165251 AK019388

GenPept

BAB31694

RNA Seq Atlas

77134