InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Casr

Summary

InnateDB Gene

IDBG-158013.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casr

Gene Name

calcium-sensing receptor

Synonyms

CaR; Gprc2a

Species

Mus musculus

Ensembl Gene

ENSMUSG00000051980

Encoded Proteins

IDBP-158015

calcium-sensing receptor

IDBP-250913

calcium-sensing receptor

IDBP-622098

calcium-sensing receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000036828:
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:36493696-36562141

Strand

Reverse strand

Band

Transcripts

ENSMUST00000063597	ENSMUSP00000069080
ENSMUST00000114847	ENSMUSP00000110496
ENSMUST00000172826	ENSMUSP00000133500
ENSMUST00000174750

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004930	G-protein coupled receptor activity
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0008144	drug binding
GO:0019808	polyamine binding
GO:0019901	protein kinase binding
GO:0044325	ion channel binding

Biological Process

GO:0001503	ossification
GO:0002931	response to ischemia
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006915	apoptotic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007254	JNK cascade
GO:0008284	positive regulation of cell proliferation
GO:0010038	response to metal ion
GO:0010628	positive regulation of gene expression
GO:0014070	response to organic cyclic compound
GO:0032024	positive regulation of insulin secretion
GO:0032781	positive regulation of ATPase activity
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0042311	vasodilation
GO:0045907	positive regulation of vasoconstriction
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050927	positive regulation of positive chemotaxis
GO:0051592	response to calcium ion
GO:0051924	regulation of calcium ion transport
GO:0060613	fat pad development
GO:0071305	cellular response to vitamin D
GO:0071333	cellular response to glucose stimulus
GO:0071404	cellular response to low-density lipoprotein particle stimulus
GO:0071456	cellular response to hypoxia
GO:0071774	response to fibroblast growth factor
GO:0090280	positive regulation of calcium ion import
GO:1901653	cellular response to peptide

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030424	axon
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043679	axon terminus