InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casr

Summary

InnateDB Protein

IDBP-158015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casr

Protein Name

calcium-sensing receptor

Synonyms

CaR; Gprc2a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069080

InnateDB Gene

IDBG-158013 (Casr)

Protein Structure

UniProt Annotation

Function

Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Epidermis, kidney and cartilage. {ECO:0000269PubMed:10579354, ECO:0000269PubMed:10625662, ECO:0000269PubMed:10652312, ECO:0000269PubMed:9076582}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004930	G-protein coupled receptor activity
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0008144	drug binding
GO:0019808	polyamine binding
GO:0019901	protein kinase binding
GO:0044325	ion channel binding

Biological Process

GO:0001503	ossification
GO:0002931	response to ischemia
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006915	apoptotic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007254	JNK cascade
GO:0008284	positive regulation of cell proliferation
GO:0010038	response to metal ion
GO:0010628	positive regulation of gene expression
GO:0014070	response to organic cyclic compound
GO:0032024	positive regulation of insulin secretion
GO:0032781	positive regulation of ATPase activity
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0042311	vasodilation
GO:0045907	positive regulation of vasoconstriction
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050927	positive regulation of positive chemotaxis
GO:0051592	response to calcium ion
GO:0051924	regulation of calcium ion transport
GO:0060613	fat pad development
GO:0071305	cellular response to vitamin D
GO:0071333	cellular response to glucose stimulus
GO:0071404	cellular response to low-density lipoprotein particle stimulus
GO:0071456	cellular response to hypoxia
GO:0071774	response to fibroblast growth factor
GO:0090280	positive regulation of calcium ion import
GO:1901653	cellular response to peptide

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030424	axon
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043679	axon terminus

Protein Structure and Domains

PDB ID

MGI:1351351

InterPro

IPR000337 GPCR, family 3
IPR001828 Extracellular ligand-binding receptor
IPR004073 GPCR, family 3, vomeronasal receptor, type 2
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF07562
PF00003

PRINTS

PR00248
PR01535

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QY96