InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mbl2

Summary

InnateDB Gene

IDBG-158106.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mbl2

Gene Name

mannose-binding lectin (protein C) 2

Synonyms

L-MBP; MBL; MBL-C; MBP-C

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024863

Encoded Proteins

IDBP-158108

mannose-binding lectin (protein C) 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20375621

Mbl2 interacts with Fcna and fibrinogen/fibrin to augment the lectin complement pathway, which collaborates with the coagulation system in the first-line host defence against pathogens under conditions such as injury and inflammation.

PMID 21383675

Mbl2 treatment inhibits the activity of NFKB and consequently suppresses the production Tnf and Il12 production in human monocytes stimulated with LPS. In addition, Mbl2 was found to bind to Tlr4 and attenuate the binding of LPS to cell surfaces.

InnateDB Annotation from Orthologs

Summary

PMID 16105157

[Homo sapiens] MBL2 is a major recognition molecule of the lectin pathway of complement.

PMID 16911830

[Homo sapiens] MBL2 binds directly to a wide range of repeating sugar moieties on microbial surfaces via its lectin domain, resulting in neutralization and opsonization.

PMID 19840833

[Homo sapiens] MBL2 binds toll-like receptor 4 (TLR4) and modulates cellular responses by altering signals through TLRs.

PMID 21383675

[Homo sapiens] MBL2 treatment inhibits the activity of NFKB and consequently suppresses the production TNF and IL12 production in human monocytes stimulated with LPS. In addition, MBL2 was found to bind to TLR4 and attenuate the binding of LPS to cell surfaces.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165471:
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:30232928-30239685

Strand

Forward strand

Band

Transcripts

ENSMUST00000025797

ENSMUSP00000025797

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005537	mannose binding
GO:0030246	carbohydrate binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001867	complement activation, lectin pathway
GO:0006958	complement activation, classical pathway
GO:0044130	negative regulation of growth of symbiont in host
GO:0045087	innate immune response (InnateDB)
GO:0048525	negative regulation of viral process
GO:0050766	positive regulation of phagocytosis
GO:0050830	defense response to Gram-positive bacterium
GO:0051873	killing by host of symbiont cells