Version 5.4
Homo sapiens Gene: MBL2
Summary
InnateDB Gene IDBG-74690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MBL2
Gene Name mannose-binding lectin (protein C) 2, soluble
Synonyms COLEC1; HSMBPC; MBL; MBL2D; MBP; MBP-C; MBP1; MBPD
Species Homo sapiens
Ensembl Gene ENSG00000165471
Encoded Proteins
IDBP-74692
mannose-binding lectin (protein C) 2, soluble
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 16105157
MBL2 is a major recognition molecule of the lectin pathway of complement.
PMID 16911830
MBL2 binds directly to a wide range of repeating sugar moieties on microbial surfaces via its lectin domain, resulting in neutralization and opsonization.
PMID 19840833
MBL2 binds toll-like receptor 4 (TLR4) and modulates cellular responses by altering signals through TLRs.
PMID 21383675
MBL2 treatment inhibits the activity of NFKB and consequently suppresses the production TNF and IL12 production in human monocytes stimulated with LPS. In addition, MBL2 was found to bind to TLR4 and attenuate the binding of LPS to cell surfaces.
InnateDB Annotation from Orthologs
Summary
PMID 20375621
[Mus musculus] Mbl2 interacts with Fcna and fibrinogen/fibrin to augment the lectin complement pathway, which collaborates with the coagulation system in the first-line host defence against pathogens under conditions such as injury and inflammation.
PMID 21383675
[Mus musculus] Mbl2 treatment inhibits the activity of NFKB and consequently suppresses the production Tnf and Il12 production in human monocytes stimulated with LPS. In addition, Mbl2 was found to bind to Tlr4 and attenuate the binding of LPS to cell surfaces.
Entrez Gene
Summary This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:52765380-52771700
Strand Reverse strand
Band q21.1
Transcripts
ENST00000373968 ENSP00000363079
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005537 mannose binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001867 complement activation, lectin pathway
GO:0006953 acute-phase response
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0006979 response to oxidative stress
GO:0008228 opsonization
GO:0042742 defense response to bacterium
GO:0044130 negative regulation of growth of symbiont in host
GO:0045087 innate immune response (InnateDB)
GO:0048525 negative regulation of viral process
GO:0050766 positive regulation of phagocytosis
GO:0050830 defense response to Gram-positive bacterium
GO:0051873 killing by host of symbiont cells
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005615 extracellular space
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024863
View Gene Order
ENSBTAG00000007049
Not yet available
Pathways
NETPATH
REACTOME
REACT_7964
Lectin pathway of complement activation pathway
REACT_8024
Initial triggering of complement pathway
REACT_6802
Innate Immune System pathway
REACT_8012
Creation of C4 and C2 activators pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05150
Staphylococcus aureus infection pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.499674
RefSeq NM_000242 XM_006717861
HUGO
OMIM
CCDS CCDS7247
HPRD 01107
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca