Version 5.4
Mus musculus Gene: Exosc5
Summary
InnateDB Gene IDBG-158160.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Exosc5
Gene Name exosome component 5
Synonyms D7Wsu180e
Species Mus musculus
Ensembl Gene ENSMUSG00000061286
Encoded Proteins
IDBP-158162
exosome component 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077348:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:25659153-25668031
Strand Forward strand
Band A3
Transcripts
ENSMUST00000079634 ENSMUSP00000078580
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006364 rRNA processing
GO:0006401 RNA catabolic process
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0045006 DNA deamination
GO:0051607 defense response to virus
Cellular Component
GO:0000178 exosome (RNase complex)
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0035327 transcriptionally active chromatin
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000077348
View Gene Order
ENSBTAG00000016034
Not yet available
Pathways
NETPATH
REACTOME
REACT_252013
mRNA decay by 3' to 5' exoribonuclease pathway
REACT_198687
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_198696
KSRP destabilizes mRNA pathway
REACT_233572
Gene Expression pathway
REACT_235784
Deadenylation-dependent mRNA decay pathway
KEGG
mmu03018
RNA degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24915
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
REACT_25064
Tristetraprolin (TTP) destabilizes mRNA pathway
REACT_25042
KSRP destabilizes mRNA pathway
REACT_20619
mRNA decay by 3' to 5' exoribonuclease pathway
REACT_18355
ATF4 activates genes pathway
REACT_18277
PERK regulates gene expression pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_17015
Metabolism of proteins pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt Q9CRA8
TrEMBL
UniProt Splice Variant
Entrez Gene 27998
UniGene
RefSeq NM_138586
OMIM
CCDS CCDS20990
HPRD
IMGT
MGI ID MGI:107889
MGI Symbol Exosc5
EMBL AK006475 AK007372 BC034358
GenPept AAH34358 BAB24607 BAB24993
RNA Seq Atlas 27998

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca